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The company peddled theories of “pseudo-addiction” (for which the cure was said to be more opioids) and of “opiophobia” among sceptical doctors.
The guardrails against harm buckled in the face of Purdue’s wealth and the lawyers and lobbyists it could buy.
Regulators endorsed ludicrous claims about the drug’s safety.
A serious case brought by federal prosecutors in Virginia in the early 2000s was watered down by the Department of Justice.
Thousands of doctors were given all-expenses-paid trips.
Altogether, OxyContin took in $35bn in sales.
The results were brutal.
Other drug manufacturers soon followed Purdue’s lead.
When OxyContin was reformulated in 2010 to make it more difficult to abuse,
many Americans who were already addicted switched to heroin and, eventually, fentanyl.
In 2019 a team of economists rigorously evaluating OxyContin’s impact concluded that
its introduction and marketing “explain a substantial share of overdose deaths” over 20 years.
Purdue is now the subject of many lawsuits brought by state and city governments.
Sifting through the reams of evidence unearthed by court proceedings,
Mr Keefe shows how callous some of the remaining Sacklers have been over the destruction wrought around them―
blaming the problem on immoral addicts rather than the drug, and regarding themselves as victims of a media witch-hunt.
Shiftless third-generation types are rendered with evident loathing,
普渡制药公司向持怀疑态度的医生散播“假性成瘾”(据说治疗方法是服用更多的阿片类药物)和“阿片药恐惧症”的理论。
普渡制药的财富以及它能够收买的律师和说客让防范危险的护栏垮了。
监管机构认可了有关奥施康定安全性的荒唐说法。
本世纪初,弗吉尼亚州联邦检察官提起的一起严重案件被司法部大事化了。
普渡制药还承担了数千名医生的全部旅行费用。
奥施康定的总销售额为350亿美元。
结果很残酷。
其他药品生产商很快效仿了普渡制药公司的做法。
2010年,普渡制药公司重新配制了奥施康定,使其更难滥用,
许多已经上瘾的美国人因此转而使用海洛因,最终使用芬太尼。
2019年,一个由经济学家组成的团队对奥施康定的影响进行了严格评估并得出结论:
奥施康定的推出和销售“能够对20年来用药过量致死中的相当一部分进行解释”。
普渡制药现在仍面临多个州和市政府提起的诉讼。
通过筛选法庭诉讼中发现的大量证据,
基夫先生展示了剩下的一些萨克勒家族成员在面对自己对周围造成的破坏时是多么冷酷无情,
他们将问题归咎于不道德的瘾君子而不是毒品本身,并将自己视为遭受媒体政治迫害的受害者。
无能的第三代萨克勒家族成员呈现出明显的厌恶情绪,
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